By Philip W. Harvey, David J. Everett, Christopher J. Springall

Despite being considered as the most typical toxicological objective within the endocrine method, the adrenal gland has usually been missed in regulatory trying out. Adrenal Toxicology addresses the elevated curiosity in adrenocortical toxicology and the necessity for a source that makes thoughts on hand to ascertain adrenal endocrine disruption.

Examining present recommendations and the most recent developments, Adrenal Toxicology stories the endocrinology, pharmacology, pathology and toxicology of the adrenal gland. this article offers info at the variety of substances and chemical compounds that have an effect on adrenocortical functionality and indicates standardized techniques for in vivo and in vitro overview. This quantity additionally provides contemporary advancements within the molecular mechanisms of toxicity to the adrenal cortex and medulla, and considers environmental adrenal endocrine disruption in sentinel species.

Adrenal Toxicology :

  • reflects the foremost advancements revamped the earlier decade
  • focuses at the most up-to-date examine strategies, together with their makes use of and limitations
  • provides an built-in procedure for adrenal toxicology evaluation
  • identifies wisdom and information gaps, delivering impetus for regulatory consideration

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Example text

2007). The ability of untreated rats to respond to an ACTH challenge by markedly increased corticosterone secretion, compared with test compound treated rats that cannot respond, would provide strong evidence of adrenocortical suppression. , if basal corticosterone was low, but adequate upon ACTH challenge, it could be concluded that pituitary function was deficient rather than the adrenal). The use of an in vitro system, such as the H295R cell line, could then be employed as a second tier to elucidate mechanisms of action and provide evidence for, or exclude, direct adrenocortical effects such as altered StAR function or enzyme inhibition.

Effects of currently used pesticides in assays for estrogenicity and aromatase activity in vitro. Toxicol Appl Pharmacol 2000; 179:1–12. Baldwin JA. Glucocorticosteroids, stress, and developmental toxicology. In: Harvey PW, ed. The adrenal in toxicology: Target organ and modulator of toxicity. London: Taylor & Francis; 1996:223—242. Baos R, Blas J, Bortolotti GR, et al. Adrenocortical response to stress and thyroid status in free-living nestling white storks (Ciconia ciconia) exposed to heavy metal and arsenic contamination.

J Appl Toxicol 2007; 27:103–115. Harvey PW. Stress and toxicity. Hum Exp Toxicol 1994; 13:275–276. Harvey PW. An overview of adrenal gland involvement in toxicology. In: Harvey PW, ed. The Adrenal in Toxicology: Target Organ and Modulator of Toxicity. London: Taylor & Francis, 1996a:3–19. 28 Harvey et al. Harvey PW. Glucocorticosteroid modulation of toxicity. In: Harvey PW, ed. The Adrenal in Toxicology: Target Organ and Modulator of Toxicity. London: Taylor & Francis, 1996b:185–204. Healing G.

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Adrenal Toxicology by Philip W. Harvey, David J. Everett, Christopher J. Springall
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