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99. H. Gogerty, W. Houlihan, M. Galen, P. Eden and C. Penberthy, Fed. , 501 (1968). 100. K. Pfeifer, L. Gyorgy and M. Fodor, Acta. Med. Acad. Sci. , 5,441 (1968). 101. F. L. R. Norvich and JV . Dingell, Psychopharmacologia, 322 (1968). 102. -H. P. Magnussen, Biochem. , lJ1299 (19681, 103. C. Baird, J. Pharm. , 20, 234 (1968). 104. L. Valzelli, E. D o l f i n i , M. l a n s e l l a and S. ,g, 595 (1968); cf. C. Morpurgo and W. Theobald, Europ. J. , 2, 287 (1968). 105, RM. N. Latimer, Psychopharmacologia, L ?

I1 - P h a r m a c o d y n a m i c Agents Bloom, Ed. h i b i t o r R0-4-4602. The response t o exogenous norepinephrine was not a f f e c t e d . I11 IV Blood pressure was lowered i n rats and c a t s by 11142 without a f f e c t i n g t h e pressor response t o norepinephrine. Response t o tyramine was i n h i b i t e d . The guanidine I V showed a guanethidine type of hypot e n s i v e a c t i o n i n hypertensive dogst3 Blood pressure could b e c o n t r o l l e d without emesis and diarrhea i n t h e dogs--unlike guanethidine.

165(a) T i Lidz and A. Rothenberg; Psychiatry, 766 (1968). 166. Amer. J. , 341-393 (1968). X. freedman, Arch. Gen. B. Louria, New England J. , 278, 174 (1968). J. Schwarz, J. Nerv. Ment. G. Smart and K. Bateman, Can. Med. Ass. A. M. Taylor, C. U. B. R. Paton, J. Amer. Med. Ass,, 206, 2287 (1968). 169. E. K. K. Gillespie, Clin. Pharmacol. , 3 ', 783 (1968). 170. E . Heim, H. Heimann and G. LukCs, Psychopharmacologia, rJ, 35 (1968). 171. W. Theobald, 0. A. Kunz, P. C. Stenger and H. , l8, 311 (1968).

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Annual Reports in Medicinal Chemistry, 4 by C K Cain
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